Marie-Lise Gougeon

Bio:• Marie-Lise Gougeon is heading the « Antiviral Immunity, Biotherapy and Vaccine » unit at Institut Pasteur. She has a long-standing interest in deciphering the viral strategies developed by persistent viruses to escape immune attack. Recently, her research addressed the question of the contribution of innate immunity to the control of HIV infection, focusing particularly on the role of alarmins (such as HMGB1) in the constitution of HIV reservoirs in dendritic cells.
• Moreover, her unit has been actively involved these last 10 years in the immunomonitoring of vaccine trials. She has set up a platform developing new tools with multiparametric approaches, with the aim to 1- thoroughly characterize the immune response to candidate vaccines in phase I and phase II clinical trials; 2- Identify immune signatures and correlates of protection. Recently, her team evaluated the immunogenicity of a live attenuated new candidate vaccine against Shigella dysenteriae-1, developed in Philippe Sansonetti’s laboratory. This phase 2 trial showed that a single oral immunization of SC599 vaccine in healthy volunteers elicited significant circulating IgA antibody secreting cell and serum antibody responses that may confer protection against the most severe symptoms of Shigellosis in responders to the vaccine (Launay O et al. Vaccine, 2009). As a partner of Stopenterics consortium, ML Gougeon’s team will further develop new tools to better characterize innate and adaptive immunity specific for Shigella, both in the context of natural infection and vaccine responses.

Selected publications (Citation index from ISI Web of Knowledge, November 2012)

Seror, C*., Melki, MT*., Subra, F*., et al. 2011. Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection .
J. Exp. Med., 208 :1828-34 (* co-first authors)

Melki, MT., Saidi, H., Dufour, A., Olivo-Marin, JC., Gougeon, ML. 2010. Escape of HIV-1-infected dendritic cells from TRAIL-Mediated NK cell cytotoxicity during NK-DC cross-talk-A pivotal role of HMGB1. PloS Pathog. 6 : e1000862

Launay, O., Sadorge, C., Jolly, N., Poirier, B., Béchet, S., van der Vliet, D., Seffer, V., Fenner, N., Dowling, K., Giemza, R., Johnson, Ndiaye, A., Vray, M., Sansonetti, P., Morand, P,. Poyart, C., Lewis, D., Gougeon, ML. 2009. Safety and immunogenicity of SC599, an oral live attenuated Shigella dysenteriae type-1 vaccine in healthy volunteers: results of a Phase 2, randomized, double-blind placebo-controlled trial. Vaccine. 18;27(8):1184-91

Joly P, Mouquet H, Roujeau JC, D'Incan M, Gilbert D, Jacquot S, Gougeon ML et al. 2007. A single cycle of Rituximab for the treatment of severe pemphigus.
N Engl J Med. 2007, 357:545-52 (No Cited : 123)

Gougeon, ML., Penicaud, L., Fromenty, B., Leclercq, P., Viard, JP., Capeau, J. 2004. Adipocytes targets and actors in the pathogenesis of HIV-associated lipodystrophy and metabolic alterations.
Antiviral Therapy ; 9:161-177. (No Cited : 77)

Gougeon, ML. 2003. Apoptosis as an HIV strategy to escape immune attack.
Nature Rev. Immunol. 3 : 392-404 (No Cited : 144)

Ledru, E., Christeff, N., Patey, O., de Truchis, P., Melchior, JC., Gougeon ML. 2000. Alteration of tumor necrosis factor-alpha T-cell homeostasis following potent antiretroviral therapy: contribution to the development of human immunodeficiency virus-associated lipodystrophy syndrome.
Blood., 95 :3191-98. (No Cited : 134)

Poccia, F., Cipriani, B., Vendetti, S., Colizzi, V., Poquet, Y., Battistini, L., López-Botet, M., Fournié, JJ., Gougeon, ML. 1997. CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive V?9Vd2 T lymphocytes. J Immunol. 159:6009 (No Cited : 118).

Petit, X., Lecoeur, H., Zorn, E., Dauguet, C., Mignotte, B., Gougeon, ML. 1995. Alterations in mitochondrial structure and function are early events of dexamethasone-induced apoptosis.
J. Cell Biology, 130:157 (No Cited : 447)

Gougeon, ML., Montagnier, L. 1993. Apoptosis in AIDS.
Science., 260 : 1269-1270 (No Cited : 318)
Phone:+ 33 1 4568 8907
Fax:+ 33 1 4568 8909
Address:Innate immunity and viruses Unit, Institut Pasteur, Paris
25-28 rue du Dr. Roux, 75724 Paris Cedex 15
FR - France

Last update: Friday, August 26, 2011
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